New insights into the control of stem cell pluripotency

Paul J Gokhale; Peter W Andrews

doi:10.1016/j.stem.2007.12.007

New insights into the control of stem cell pluripotency

Cell Stem Cell. 2008 Jan 10;2(1):4-5. doi: 10.1016/j.stem.2007.12.007.

Authors

Paul J Gokhale¹, Peter W Andrews

Affiliation

¹ Centre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.

PMID: 18371412
DOI: 10.1016/j.stem.2007.12.007

Abstract

Nanog is a transcription factor that is expressed by mouse and human embryonic stem (ES) cells and by primordial germ cells. New research published recently in Nature (Chambers et al., 2007) points to an unexpected role for Nanog in the maintenance of pluripotency in mouse ES cells.

Publication types

Editorial

MeSH terms

Animals
Cell Differentiation
Embryonic Stem Cells / physiology*
Feedback, Physiological
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Homeodomain Proteins / physiology*
Humans
Mice
Nanog Homeobox Protein
Octamer Transcription Factor-3 / physiology
Pluripotent Stem Cells / cytology
Pluripotent Stem Cells / physiology*
SOXB1 Transcription Factors / physiology

Substances

Homeodomain Proteins
NANOG protein, human
Nanog Homeobox Protein
Octamer Transcription Factor-3
POU5F1 protein, human
SOX2 protein, human
SOXB1 Transcription Factors