How do mesenchymal stromal cells suppress T cells?

Cell Stem Cell. 2008 Feb 7;2(2):106-8. doi: 10.1016/j.stem.2008.01.007.

Abstract

Accumulating information indicates that mesenchymal stem or stromal cells (MSCs) are immunomodulatory, but the data to explain the observations are frequently conflicting. In this issue of Cell Stem Cell, Ren et al. (2008) provide evidence for a possible underlying mechanism of MSC-mediated T cell suppression. A perspective for considering these interesting observations is discussed.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Proliferation / drug effects
  • Chemokines / metabolism
  • Chemokines / pharmacology
  • Humans
  • Mesenchymal Stem Cells / immunology*
  • Mesenchymal Stem Cells / metabolism
  • Models, Biological
  • Nitric Oxide / metabolism
  • Nitric Oxide / pharmacology
  • Suppressor Factors, Immunologic / metabolism
  • Suppressor Factors, Immunologic / pharmacology
  • T-Lymphocytes, Regulatory / drug effects
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Chemokines
  • Suppressor Factors, Immunologic
  • Nitric Oxide