Directing stem cell homing

Cell Stem Cell. 2008 Mar 6;2(3):198-200. doi: 10.1016/j.stem.2008.02.012.

Abstract

Stem cell-based regeneration depends partly on the delivery of stem cells to the damaged area. Recently in Nature Medicine, Sackstein et al. (2008) report that ex vivo fucosylation of surface CD44 promoted efficient adhesive interactions of manipulated mesenchymal stem cells with marrow vasculature and subsequent homing to endosteal surfaces.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow / blood supply
  • Bone Marrow / metabolism
  • Cell Adhesion / physiology
  • Humans
  • Hyaluronan Receptors / metabolism*
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / physiology*
  • Regeneration / physiology*

Substances

  • CD44 protein, human
  • Hyaluronan Receptors