Intra-abdominal infections (IAIs) are a frequent cause of mobility and mortality. These infections can be caused by a wide variety of microorganisms, including both aerobes and anaerobes, and are often polymicrobial. Several studies observed that mortality depends on initiating early appropriate antimicrobial therapy. Moreover, the inappropriate choice of initial antibiotic therapy result in a longer hospital stay and higher costs of hospitalization compared with appropriate initial antibiotic therapy. The aim of current review is that of summarize the recommendations of several guidelines on the management of IAIs.