Eosinophilic gastrointestinal diseases may affect the colon; however, isolated colonic involvement is very rare. Diagnosis of eosinophilic colitis requires clinical suspicion and it should be differentiated from other disorders causing eosinophil accumulation in the colon tissue. Herein we present a 46-year-old female admitted to the hospital with the complaints of bloody diarrhea (25-30 times a day), fever, abdominal pain and weight loss. Eosinophilic colitis was diagnosed and she was treated with steroid successfully.