Abstract
T lymphocytes recognize antigens via transmembrane heterodimers, their T cell receptors (TCR). T cells express either TCR alpha beta or TCR gamma delta isotypes. Several molecular mechanisms are employed to diversify the TCR repertoire. Ontogeny, transcriptional regulation, and control of TCR expression will be discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Base Sequence
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DNA / genetics
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Gene Expression Regulation
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Gene Rearrangement, T-Lymphocyte
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Genetic Variation
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Mice
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Molecular Sequence Data
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, alpha-beta / metabolism*
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Receptors, Antigen, T-Cell, gamma-delta / metabolism*
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Transcription, Genetic
Substances
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta
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DNA