Abstract
Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to have statistically significant degrees of concordance with linezolid.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetamides / pharmacology*
-
Antitubercular Agents / pharmacology*
-
Drug Resistance, Bacterial
-
Fluoroquinolones / pharmacology
-
Humans
-
Linezolid
-
Microbial Sensitivity Tests / standards
-
Mycobacterium tuberculosis / drug effects*
-
Mycobacterium tuberculosis / isolation & purification
-
Oxazolidinones / pharmacology*
-
Taiwan / epidemiology
-
Tuberculosis / epidemiology
-
Tuberculosis / microbiology*
-
Tuberculosis, Multidrug-Resistant / epidemiology
-
Tuberculosis, Multidrug-Resistant / microbiology*
Substances
-
Acetamides
-
Antitubercular Agents
-
Fluoroquinolones
-
Oxazolidinones
-
Linezolid