Abstract
Chronic deteriorating renal function and renal fibrosis are common features in progressive renal diseases. Renal fibrosis may determine the degree of impairment of renal function and predict long-term prognosis. Advances in cell biology have provided a new understanding of the molecular events underlying renal fibrosis. A central event in tissue repair is the release of cytokines, i.e. transforming growth factor-Beta, in response to injury. The sustained expression of these cytokines underlies the development of renal fibrosis. Understanding the molecular mechanisms of the cytokines and their signaling could lead to the application of clinically useful gene therapy.
MeSH terms
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Connective Tissue Growth Factor
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Disease Progression
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Fibrosis
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Genetic Therapy / methods
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Hepatocyte Growth Factor / genetics
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Hepatocyte Growth Factor / therapeutic use
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Humans
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Immediate-Early Proteins / genetics
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Immediate-Early Proteins / therapeutic use
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / therapeutic use
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Kidney Failure, Chronic / genetics
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Kidney Failure, Chronic / pathology*
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Kidney Failure, Chronic / therapy
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Oligonucleotides, Antisense / therapeutic use
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Platelet-Derived Growth Factor / genetics
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Platelet-Derived Growth Factor / therapeutic use
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RNA Interference
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RNA, Catalytic / therapeutic use
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Transcription Factors / genetics
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Transcription Factors / therapeutic use
Substances
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CCN2 protein, human
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Immediate-Early Proteins
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Intercellular Signaling Peptides and Proteins
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Oligonucleotides, Antisense
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Platelet-Derived Growth Factor
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RNA, Catalytic
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Transcription Factors
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Connective Tissue Growth Factor
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Hepatocyte Growth Factor