Abstract
BAD, a proapoptotic member of the Bcl-2 family of proteins, is regulated by phosphorylation. A recent study (Danial et al., 2008) suggests a phosphorylation-state-dependent bifunctional role of BAD in the regulation of glucose-stimulated insulin secretion and beta cell mass.
MeSH terms
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Apoptosis
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Diabetes Mellitus, Type 2 / pathology
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Diabetes Mellitus, Type 2 / physiopathology
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Glucose / metabolism
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Insulin / metabolism
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Insulin Secretion
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Insulin-Secreting Cells / cytology
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Insulin-Secreting Cells / metabolism*
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Phosphorylation
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bcl-Associated Death Protein / chemistry*
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bcl-Associated Death Protein / metabolism*
Substances
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Insulin
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bcl-Associated Death Protein
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Glucose