Abstract
We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects
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Carcinoma / drug therapy*
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Carcinoma / pathology
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Cell Line, Tumor
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Lethal Dose 50
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Microscopy, Confocal
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Mitochondria / drug effects
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry*
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Organometallic Compounds / pharmacology*
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Spectrometry, Fluorescence
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Thiosemicarbazones / chemistry*
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Toxicity Tests
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Zinc / chemistry*
Substances
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Organometallic Compounds
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Thiosemicarbazones
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Zinc