Abstract
We report on our experience with the intra-arterial administration of eptifibatide for thrombolysis during aneurysm-embolization procedures. In 4 cases (3 stent-assisted coiling procedures and 1 with posthemorrhagic vasospasm), we noted the formation of thrombus occluding a vessel. We administered eptifibatide (10-15 mg) through a microcatheter proximal to the thrombus. The thrombus rapidly dissolved, resulting in the recanalization of the occluded vessels with no rethrombosis or hemorrhagic complications.
MeSH terms
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Aneurysm, Ruptured / diagnostic imaging
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Aneurysm, Ruptured / therapy
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Angiography, Digital Subtraction
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Carotid Artery Diseases / diagnostic imaging
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Carotid Artery Diseases / therapy
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Carotid Artery Thrombosis / diagnostic imaging
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Carotid Artery Thrombosis / drug therapy
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Carotid Artery, Internal / diagnostic imaging
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Cerebral Angiography
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Combined Modality Therapy
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Embolization, Therapeutic*
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Eptifibatide
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Female
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Heparin / therapeutic use
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Humans
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Infusions, Intra-Arterial
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Intracranial Aneurysm / diagnostic imaging
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Intracranial Aneurysm / radiotherapy
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Intracranial Aneurysm / therapy*
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Intracranial Thrombosis / diagnostic imaging
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Intracranial Thrombosis / drug therapy*
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Intraoperative Complications / diagnostic imaging
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Intraoperative Complications / drug therapy*
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Middle Aged
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Peptides / therapeutic use*
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Platelet Aggregation Inhibitors / adverse effects
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Platelet Aggregation Inhibitors / therapeutic use*
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Stents
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Subarachnoid Hemorrhage / diagnostic imaging
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Subarachnoid Hemorrhage / therapy
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Thrombolytic Therapy*
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Vasospasm, Intracranial / diagnostic imaging
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Vasospasm, Intracranial / therapy
Substances
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Peptides
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Platelet Aggregation Inhibitors
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Heparin
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Eptifibatide