New insight into Ni(II)-catalyzed cyclization reactions of propargylic compounds with soft nucleophiles: novel indenes formation

J Org Chem. 2008 May 16;73(10):3837-41. doi: 10.1021/jo800155a. Epub 2008 Apr 15.

Abstract

We have disclosed a very nice advance of nickel(II)-catalyzed carboannulation reactions. Highly substituted indene derivatives are readily prepared in moderate to excellent yields under very mild reaction conditions in air via a nickel(II)-catalyzed cyclization of propargylic compounds with soft nucleophiles.

MeSH terms

  • Alkynes / chemistry*
  • Catalysis
  • Cyclization
  • Indenes / chemical synthesis*
  • Indenes / chemistry
  • Molecular Structure
  • Nickel / chemistry*
  • Stereoisomerism

Substances

  • Alkynes
  • Indenes
  • Nickel