Brushed aside and silenced

Lyubomira Chakalova; Peter Fraser

doi:10.1016/j.devcel.2008.03.020

Brushed aside and silenced

Dev Cell. 2008 Apr;14(4):461-2. doi: 10.1016/j.devcel.2008.03.020.

Authors

Lyubomira Chakalova¹, Peter Fraser

Affiliation

¹ Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.

PMID: 18410721
DOI: 10.1016/j.devcel.2008.03.020

Abstract

Mammalian genomes are highly organized in the 3D space of cell nuclei, but whether this affects gene function is unclear. Three papers now show that spatial relocation of a gene directly affects expression, and surprisingly, that of its neighbors.

MeSH terms

Animals
Cell Nucleus* / chemistry
Cell Nucleus* / metabolism
Chromosome Positioning
Gene Expression Regulation / physiology*
Gene Silencing*
Genome
Transcription, Genetic