Abstract
We report fabrication and characterization of a novel real-time, label-free DNA detector, that uses a long nanofluidic channel to stretch a DNA strand and a nanogap detector (with a gap as small as 9 nm) inside the channel to measure the electrical conduction perpendicular to the DNA backbone as it moves through the gap. We have observed electrical signals caused by 1.1 kilobase-pair (kbp) double-stranded (ds)-DNA passing through the gap in the nanogap detectors with a gap equal to or less than 13 nm.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Computer Systems
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DNA / analysis
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DNA / chemistry*
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DNA / genetics*
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Electrochemistry / instrumentation*
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Electrochemistry / methods
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Equipment Design
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Equipment Failure Analysis
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Microelectrodes
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Microfluidics / instrumentation*
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Microfluidics / methods
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Nanotechnology / instrumentation*
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Nanotechnology / methods
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Oligonucleotide Array Sequence Analysis / instrumentation*
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Oligonucleotide Array Sequence Analysis / methods
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Sequence Analysis, DNA / instrumentation*
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Sequence Analysis, DNA / methods
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Staining and Labeling