Sample stacking and sweeping in microemulsion electrokinetic chromatography under pH-suppressed electroosmotic flow

J Chromatogr A. 2008 May 30;1192(2):319-22. doi: 10.1016/j.chroma.2008.04.005. Epub 2008 Apr 8.

Abstract

Two on-line sample concentration techniques, sample stacking and sweeping under pH-suppressed electroosmotic flow, were evaluated in microemulsion electrokinetic chromatography. The concept of stacking with anion selective electrokinetic injection and a water plug in a reverse-migrating microemulsion (SASIW-RMME) was brought forward in this article. Six flavonoids were concentrated using a microemulsion consisting of 80 mM sodium dodecyl sulfate, 1.2% (v/v) ethyl acetate, 0.6% (v/v) 1-butanol, 10% acetonitrile (v/v) and 50 mM phosphoric acid (pH* 1.8). Significant detector response improvements were achieved. The limits of detection were in the low ng/ml level. Finally, the sample of Fructus aurantii Immaturus was analyzed using sweeping technique.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Chromatography, Micellar Electrokinetic Capillary / methods*
  • Electroosmosis
  • Emulsions
  • Flavonoids / analysis
  • Hydrogen-Ion Concentration
  • Indicators and Reagents
  • Solutions

Substances

  • Emulsions
  • Flavonoids
  • Indicators and Reagents
  • Solutions