Abstract
Several reports indicated that Alzheimer's disease (AD) and age-related macular degeneration (AMD) may share similar genetic and pathological features. We postulated that the functional Y402H polymorphism within the CFH gene and unambiguously recognised as a major genetic determinant of AMD, may also be a risk factor of AD. We analysed the association of this polymorphism with the AD risk in both prospective and cross-sectional studies. We were not able to detect such an association whatever the studied population, suggesting that the CFH gene is not a genetic determinant of AD.
MeSH terms
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Alzheimer Disease / genetics*
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Alzheimer Disease / metabolism
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Alzheimer Disease / physiopathology
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Complement Factor H / genetics
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Cross-Sectional Studies
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DNA Mutational Analysis
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Gene Frequency / genetics
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Genetic Association Studies / methods*
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Genetic Linkage / genetics
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Genetic Markers / genetics
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genotype
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Humans
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Macular Degeneration / genetics*
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Macular Degeneration / metabolism
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Macular Degeneration / physiopathology
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Polymorphism, Genetic / genetics*
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Prospective Studies
Substances
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CFH protein, human
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Genetic Markers
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Complement Factor H