Lack of association between Interleukin-18 gene promoter polymorphisms and onset of Alzheimer's disease

Ludovica Segat; Michele Milanese; Beatrice Arosio; Carlo Vergani; Sergio Crovella

doi:10.1016/j.neurobiolaging.2008.03.005

Lack of association between Interleukin-18 gene promoter polymorphisms and onset of Alzheimer's disease

Neurobiol Aging. 2010 Jan;31(1):162-4. doi: 10.1016/j.neurobiolaging.2008.03.005. Epub 2008 Apr 22.

Authors

Ludovica Segat¹, Michele Milanese, Beatrice Arosio, Carlo Vergani, Sergio Crovella

Affiliation

¹ Department of Developmental and Reproductive Sciences, University of Trieste, Via dell'Istria 65/1, 34137 Trieste, Italy. [email protected]

PMID: 18433937
DOI: 10.1016/j.neurobiolaging.2008.03.005

Abstract

In our case-control study we analyzed two functional IL18 gene promoter polymorphisms (-137G/C and -607C/A) and an additional polymorphism at position -656 (G/T) in Alzheimer patients and healthy controls in order to verify the involvement of these genetic variations in the onset of Alzheimer disease. No significant differences were detected for the three IL18 SNPs between AD patients and controls. The haplotypes distribution also did not show any difference within AD subjects and controls.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / genetics*
Alzheimer Disease / immunology*
Alzheimer Disease / physiopathology
Biomarkers
Case-Control Studies
DNA Mutational Analysis
Gene Frequency / genetics
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics*
Genetic Testing
Genotype
Humans
Interleukin-18 / genetics*
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics*

Substances

Biomarkers
Genetic Markers
Interleukin-18