According to the Centers for Disease Control and Prevention, suicide is the third leading cause of death in adolescence in the United States. Nonfatal forms of suicidal behavior are the most common reasons for the psychiatric hospitalization of adolescents in many countries. The risk for suicide attempt among offspring of suicide completers is multifactorial, challenging experts to develop a strategy that includes assessment and management that consider these factors. Although treatment of depression is necessary, antisuicide treatment strategies that solely target depression may not be sufficient to reduce suicidal risk. Other factors, such as impulsive aggression and parental history of sexual abuse, also contribute to suicidal risk.