[Listeria monocytogenes abscess of the brain]

Rev Neurol (Paris). 2008 Apr;164(4):388-93. doi: 10.1016/j.neurol.2007.09.004. Epub 2008 Feb 20.
[Article in French]

Abstract

Introduction: Listeriosis commonly involves the central nervous system. Meningoencephalitis and rhomboencephalitis are the most frequent manifestations. Brain abscesses are rare.

Case report: We report the case of a 63-year-old man treated with steroids for a long period; he was hospitalized for hemiparesis, confusion and fever. Clinical examination revealed meningeal signs, right hemiparesis and Parinaud syndrome. Initial CT scan was normal. The CSF contained 520 white cells/mm3 with predominance of polymorphonuclear neutrophils. An acute meningo- rhombencephalitis in an immunodepressed patient was suggested. The diagnosis of listeriosis was confirmed by blood cultures. Amoxicillin and gentamycin were started. The outcome on day 4 was severe with coma and tetraparesis. Brain MRI revealed a left peduncle abscess which descended deep into the brain reaching the internal capsule. The final clinical outcome involved residual right hemiparesis and left oculomotor nerve (III) palsy.

Conclusion: Brain stem abscess is an uncommon form of listerial central nervous system infection. Listeria monocytogenes infection should be considered in patients with altered cell-mediated immunity that develop local neurologic deficits, a diagnosis which pursued rapidly with repeated blood cultures. Successful treatment requires early antibiotic therapy with ampicillin and gentamycin.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Amoxicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Brain Abscess / microbiology
  • Brain Abscess / pathology*
  • Brain Stem / pathology
  • Coma / etiology
  • Gentamicins / therapeutic use
  • Humans
  • Listeriosis / microbiology
  • Listeriosis / pathology*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Ophthalmoplegia / etiology
  • Paresis / etiology
  • Quadriplegia / etiology

Substances

  • Anti-Bacterial Agents
  • Gentamicins
  • Amoxicillin