Thermodynamic characterization of a highly thermoactive extracellular pectate lyase from a new isolate Bacillus pumilus DKS1

Bioresour Technol. 2008 Nov;99(17):8088-94. doi: 10.1016/j.biortech.2008.03.032. Epub 2008 Apr 28.

Abstract

An extracellular pectate lyase (EC 4.2.2.2) was purified from the culture filtrate of a newly isolated Bacillus pumilus DKS1 grown in pectin containing medium. Using ion-exchange and gel filtration chromatography, this enzyme was purified and found to have a molecular weight of around 35kDa. The purified enzyme exhibited maximal activity at a temperature of 75 degrees C and pH 8.5. The presence of 1mM calcium and manganese enhanced pectate lyase activity and was strongly inhibited by zinc, nickel and EDTA. The thermal inactivation studies revealed an entropy-enthalpy compensation pattern below a critical temperature. The alkaliphilicity and high thermostability of this pectate lyase may have potential implications in fibre degumming.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacillus / drug effects
  • Bacillus / enzymology*
  • Bacillus / isolation & purification*
  • Binding Sites
  • Circular Dichroism
  • Electrophoresis, Polyacrylamide Gel
  • Entropy
  • Enzyme Activation / drug effects
  • Extracellular Space / drug effects
  • Extracellular Space / enzymology*
  • Hydrogen-Ion Concentration
  • Kinetics
  • Metals / pharmacology
  • Molecular Sequence Data
  • Pectins / metabolism
  • Polysaccharide-Lyases / biosynthesis
  • Polysaccharide-Lyases / chemistry*
  • Polysaccharide-Lyases / isolation & purification
  • Protein Structure, Secondary
  • Temperature*
  • Thermodynamics
  • Tryptophan

Substances

  • Metals
  • Pectins
  • Tryptophan
  • Polysaccharide-Lyases
  • pectate lyase

Associated data

  • GENBANK/EF467045