Recurrent cerebral venous thrombosis revealing paraneoplastic angiitis in Hodgkin's lymphoma

J Neurooncol. 2008 Sep;89(2):195-8. doi: 10.1007/s11060-008-9604-7. Epub 2008 May 7.

Abstract

Recurrent cerebral venous thrombosis (CVT), as a manifestation of paraneoplastic angiitis and revealing of nodular lymphocyte predominant Hodgkin's disease (NLPHD), is an extremely rare condition. We herein report a 55-year-old man who developed recurrent CVT despite efficacious anticoagulant therapy and subsequent stenting of the superior longitudinal sinus. Progressive neurological deterioration ensued and a body scan revealed axillary lymph nodes. Pathological analysis led to a diagnosis of NLPHD. Conventional angiography showed CVT and multiple arterial narrowings. A paraneoplastic primary cerebral angiitis with prominent venous structure involvement was suspected. Immunotherapy using rituximab and steroids provided a dramatic recovery. This case of CVT due to paraneoplastic cerebral angiitis is a rare condition and represents a new, very rare manifestation of nodular lymphocyte predominant Hodgkin's disease.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Murine-Derived
  • Antigens, CD20 / metabolism
  • Cerebral Angiography / methods
  • Cerebral Veins / pathology*
  • Hodgkin Disease / complications*
  • Hodgkin Disease / drug therapy
  • Hodgkin Disease / pathology
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / complications*
  • Neoplasms, Second Primary / pathology
  • Rituximab
  • Vasculitis, Central Nervous System / etiology*
  • Vasculitis, Central Nervous System / pathology
  • Venous Thrombosis / etiology*
  • Venous Thrombosis / pathology

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Antigens, CD20
  • Rituximab