Matricellular proteins at the crossroad of inflammation and cancer

Sabina Sangaletti; Mario P Colombo

doi:10.1016/j.canlet.2008.03.027

Matricellular proteins at the crossroad of inflammation and cancer

Cancer Lett. 2008 Aug 28;267(2):245-53. doi: 10.1016/j.canlet.2008.03.027. Epub 2008 May 8.

Authors

Sabina Sangaletti¹, Mario P Colombo

Affiliation

¹ Department of Experimental Oncology, Immunotherapy and Gene Therapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy.

PMID: 18471960
DOI: 10.1016/j.canlet.2008.03.027

Abstract

Some proteins of the extracellular matrix known as matricellular proteins have regulatory function in all aspects of physiological and pathological stroma rearrangement. Many aspects of their activity are related to inflammation and immune response suggesting their role in bridging inflammation and cancer.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Movement
Cytokines / metabolism
Extracellular Matrix Proteins / metabolism*
Humans
Inflammation / complications*
Inflammation / immunology
Inflammation / metabolism
Intercellular Signaling Peptides and Proteins / metabolism
Leukocytes / immunology
Mice
Neoplasms / etiology*
Neoplasms / immunology
Neoplasms / metabolism
Wound Healing

Substances

Cytokines
Extracellular Matrix Proteins
Intercellular Signaling Peptides and Proteins