SF2/ASF TORCs up translation

Mol Cell. 2008 May 9;30(3):262-3. doi: 10.1016/j.molcel.2008.04.007.

Abstract

In a recent issue of Molecular Cell, Michlewski et al. (2008) show that SF2/ASF, a splicing factor, stimulates translation initiation by directly recruiting the mammalian target of rapamycin (mTOR) to a subset of mRNAs.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Cell Cycle Proteins
  • Eukaryotic Initiation Factor-4F / genetics
  • Eukaryotic Initiation Factor-4F / metabolism
  • Humans
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism
  • Protein Biosynthesis*
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • RNA Splicing
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins
  • Serine-Arginine Splicing Factors
  • TOR Serine-Threonine Kinases

Substances

  • Adaptor Proteins, Signal Transducing
  • Cell Cycle Proteins
  • EIF4EBP1 protein, human
  • Eukaryotic Initiation Factor-4F
  • Nuclear Proteins
  • Phosphoproteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • Serine-Arginine Splicing Factors
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases