A novel five-way chromosomal translocation observed in chronic myelogenous leukemia

Katsuya Ikuta; Yoshihiro Torimoto; Junko Jimbo; Junki Inamura; Takaaki Hosoki; Motohiro Shindo; Kazuya Sato; Hiroyuki Takahashi; Yutaka Kohgo

doi:10.1016/j.cancergencyto.2008.02.002

A novel five-way chromosomal translocation observed in chronic myelogenous leukemia

Cancer Genet Cytogenet. 2008 May;183(1):69-71. doi: 10.1016/j.cancergencyto.2008.02.002.

Authors

Katsuya Ikuta¹, Yoshihiro Torimoto, Junko Jimbo, Junki Inamura, Takaaki Hosoki, Motohiro Shindo, Kazuya Sato, Hiroyuki Takahashi, Yutaka Kohgo

Affiliation

¹ Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, Japan 078-8510. [email protected]

PMID: 18474301
DOI: 10.1016/j.cancergencyto.2008.02.002

Abstract

Most patients with chronic myelogenous leukemia (CML) show a Philadelphia (Ph) chromosome with a characteristic translocation between chromosomes 9 and 22. However, there are variant complex translocations involving other chromosomes in addition to the standard translocation. We describe a case of CML showing a complex and novel chromosomal translocation involving five chromosomes, t(4;12;7;9;22).

Publication types

Case Reports

MeSH terms

Adult
Chromosomes, Human, Pair 12*
Chromosomes, Human, Pair 4*
Chromosomes, Human, Pair 7*
Cytogenetic Analysis
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Male
Models, Biological
Philadelphia Chromosome*
Translocation, Genetic*