Abstract
The prevalence and clinical relevance of SNIP/p140Cap has not been extensively investigated. Here SNIP/p140Cap mRNA expression was studied in 103 breast tumour biopsies, where it was detected in approximately 37% of tumour specimens, but not in any normal breast specimens. Expression correlated significantly with unfavourable overall survival. This suggests that SNIP/p140Cap may be a useful diagnostic and prognostic marker for breast cancer and its expression in breast cancer, but not in normal breast tissue, suggests that it may have potential as a therapeutic target.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Vesicular Transport
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Adult
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Aged
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Analysis of Variance
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Biomarkers, Tumor / metabolism*
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Breast / metabolism
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Breast Neoplasms / blood supply
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Breast Neoplasms / enzymology
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology*
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Carcinoma, Basal Cell / enzymology
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Matrix Metalloproteinase 1 / metabolism*
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Microscopy, Electron, Scanning
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Middle Aged
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Neoplasm Invasiveness
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Skin Neoplasms / enzymology
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Tumor Suppressor Proteins / metabolism*
Substances
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Adaptor Proteins, Vesicular Transport
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Biomarkers, Tumor
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SRCIN1 protein, human
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Tumor Suppressor Proteins
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Matrix Metalloproteinase 1