Six- and seven-membered 1-oxa-4-aza-2-silacyclanes as possible correctors of adaptational mechanisms

A V Kurochka; O V Agafonova; A S Losev; E A Mamaeva; S Y Bylikin; V V Negrebetsky; E P Kramarova; A G Shipov; Y I Baukov

doi:10.1155/MBD.1998.25

Six- and seven-membered 1-oxa-4-aza-2-silacyclanes as possible correctors of adaptational mechanisms

Met Based Drugs. 1998;5(1):25-33. doi: 10.1155/MBD.1998.25.

Authors

A V Kurochka¹, O V Agafonova, A S Losev, E A Mamaeva, S Y Bylikin, V V Negrebetsky, E P Kramarova, A G Shipov, Y I Baukov

Affiliation

¹ Russian State Medical University Ostrovityanov St. 1 Moscow 117869 Russia.

Abstract

The biological activity of eight 1-oxa-4-aza-2-silacyclanes with the OSiCH(2)N fragment including 6-membered 2-sila-5-morpholinones (1-3) and 4-acyl-2-silamorpholines (4-6)and previously unknown 7-membered derivatives of salicylic acid (7, 8) was studied. Compounds 1 and 3-6 show the certain antihypoxic action. Compounds 2 (40 mg/kg), 4 (20 mg/kg), 6 (40 mg/kg), 7 (20 mg/kg) and 8 (40 mg/kg) reduce the physical serviceability of intact animals. Compound 1 (20 mg/kg) influences the physical serviceability in a moderate-positive way on the background of chlorophos-poisoning. Compounds 5-8 displayed protective properties against chlorophos-poisoning at the LD(50) dose and compounds 2, 4, 5, 7 at the LD(100) dose. Influence of compounds 1 and 2 on the emotional-research behavior of mice was studied.