Computational design and discovery of conformationally flexible inhibitors of acetohydroxyacid synthase to overcome drug resistance associated with the W586L mutation

ChemMedChem. 2008 Aug;3(8):1203-6. doi: 10.1002/cmdc.200800103.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetolactate Synthase / antagonists & inhibitors*
  • Acetolactate Synthase / chemistry
  • Acetolactate Synthase / genetics
  • Acetolactate Synthase / metabolism*
  • Computational Biology
  • Drug Design*
  • Drug Resistance / drug effects*
  • Drug Resistance / genetics*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Kinetics
  • Leucine / genetics
  • Leucine / metabolism
  • Models, Molecular
  • Molecular Conformation
  • Mutation / genetics
  • Tryptophan / genetics
  • Tryptophan / metabolism

Substances

  • Enzyme Inhibitors
  • Tryptophan
  • Acetolactate Synthase
  • Leucine