The role of Cdc14 phosphatases in the control of cell division

Biochem Soc Trans. 2008 Jun;36(Pt 3):436-8. doi: 10.1042/BST0360436.

Abstract

The periodicity of CDKs (cyclin-dependent kinases) regulates most cell cycle transitions including cytokinesis. High Cdk1 activity promotes cytoskeletal rearrangements necessary for cell division while at the same time ensuring that cytokinesis does not begin before the separation of sister chromatids during anaphase. The conserved Cdc14 (cell division cycle 14)-family of phosphatases reverses Cdk phosphorylation events and therefore Cdc14 phosphatases promote the process of cytokinesis. Here, we review the elucidated roles of Cdc14 phosphatases in cytokinesis and the current outstanding questions regarding their function in this process.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division*
  • Humans
  • Phosphoprotein Phosphatases / metabolism*
  • Protein Transport
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / enzymology
  • Schizosaccharomyces / cytology
  • Schizosaccharomyces / enzymology
  • Signal Transduction

Substances

  • Phosphoprotein Phosphatases