Poised RNA polymerase II gives pause for thought

Thanasis Margaritis; Frank C P Holstege

doi:10.1016/j.cell.2008.04.027

Poised RNA polymerase II gives pause for thought

Cell. 2008 May 16;133(4):581-4. doi: 10.1016/j.cell.2008.04.027.

Authors

Thanasis Margaritis¹, Frank C P Holstege

Affiliation

¹ Department of Physiological Chemistry, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

PMID: 18485867
DOI: 10.1016/j.cell.2008.04.027

Abstract

Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation*
Genome
Humans
Models, Genetic
Promoter Regions, Genetic
RNA Polymerase II / metabolism*
Transcription, Genetic*

Substances

RNA Polymerase II