Fiber formation across the bacterial outer membrane by the chaperone/usher pathway

Cell. 2008 May 16;133(4):640-52. doi: 10.1016/j.cell.2008.03.033.

Abstract

Gram-negative pathogens commonly exhibit adhesive pili on their surfaces that mediate specific attachment to the host. A major class of pili is assembled via the chaperone/usher pathway. Here, the structural basis for pilus fiber assembly and secretion performed by the outer membrane assembly platform--the usher--is revealed by the crystal structure of the translocation domain of the P pilus usher PapC and single particle cryo-electron microscopy imaging of the FimD usher bound to a translocating type 1 pilus assembly intermediate. These structures provide molecular snapshots of a twinned-pore translocation machinery in action. Unexpectedly, only one pore is used for secretion, while both usher protomers are used for chaperone-subunit complex recruitment. The translocating pore itself comprises 24 beta strands and is occluded by a folded plug domain, likely gated by a conformationally constrained beta-hairpin. These structures capture the secretion of a virulence factor across the outer membrane of gram-negative bacteria.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Biosynthetic Pathways*
  • Crystallography, X-Ray
  • Escherichia coli / chemistry*
  • Escherichia coli / metabolism
  • Escherichia coli Proteins / chemistry
  • Escherichia coli Proteins / metabolism
  • Escherichia coli Proteins / ultrastructure
  • Fimbriae Proteins / chemistry
  • Fimbriae Proteins / metabolism*
  • Fimbriae Proteins / ultrastructure
  • Fimbriae, Bacterial / ultrastructure*
  • Models, Molecular
  • Molecular Chaperones / metabolism*
  • Molecular Sequence Data
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / metabolism
  • Porins / chemistry
  • Porins / metabolism

Substances

  • Escherichia coli Proteins
  • Molecular Chaperones
  • Multiprotein Complexes
  • Porins
  • atpG protein, E coli
  • fimC protein, E coli
  • fimD protein, E coli
  • Fimbriae Proteins

Associated data

  • PDB/2VQI