Population data and mutation rate of nine Y-STRs in a mestizo Mexican population from Guadalajara, Jalisco, México

Jorge Ramón Padilla-Gutiérrez; Yeminia Valle; Antonio Quintero-Ramos; Guillermo Hernández; Katya Rodarte; Rocío Ortiz; Norma Olivares; Fernando Rivas

doi:10.1016/j.legalmed.2008.03.004

Population data and mutation rate of nine Y-STRs in a mestizo Mexican population from Guadalajara, Jalisco, México

Leg Med (Tokyo). 2008 Nov;10(6):319-20. doi: 10.1016/j.legalmed.2008.03.004. Epub 2008 May 16.

Authors

Jorge Ramón Padilla-Gutiérrez¹, Yeminia Valle, Antonio Quintero-Ramos, Guillermo Hernández, Katya Rodarte, Rocío Ortiz, Norma Olivares, Fernando Rivas

Affiliation

¹ Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, Colonia Independencia, Guadalajara, Jalisco 44340, Mexico. [email protected]

PMID: 18486519
DOI: 10.1016/j.legalmed.2008.03.004

Abstract

Nine Y-STR (DYS19, DYS390, DYS391, DYS392, DYS446, DYS447, DYS448, DYS456 and DYS458) were analyzed in a male sample of 285 unrelated individuals from Guadalajara, Jalisco, México. The haplotype diversity (0.996) and discrimination capacity (0.986) were calculated. A family study of around 200 father/son pairs and among 1828 meiosis showed five mutational events. All mutations were single step. The overall mutation rate estimated across the nine Y-STRs was 2.7 x 10(-3) (95% CI 1.2-6.4 x 10(-3))/locus/meiosis. The results indicate that these nine loci are useful Y-linked markers for forensic applications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Y / genetics*
DNA Mutational Analysis*
Ethnicity / genetics*
Gene Frequency
Genetic Variation
Genetics, Population
Humans
Male
Mexico / ethnology
Microsatellite Repeats / genetics*