Abstract
The amino acid sequence of the polyprotein deduced from the nucleotide sequence of the Japanese hepatitis C virus genome (N. Kato et al. (1990) Proc. Natl. Acad. Sci. USA 87, 9524-9528) indicated that this virus is a member of a new class of positive-stranded RNA viruses. Several domains of this polyprotein also showed weak homology with those of flaviviruses and pestiviruses including the chymotrypsin-like serine proteinase, NTPase and RNA-dependent RNA polymerase.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Chymotrypsin / chemistry
-
Chymotrypsin / genetics
-
Flavivirus / genetics
-
Hepacivirus / genetics*
-
Molecular Sequence Data
-
Nucleoside-Triphosphatase
-
Pestivirus / genetics
-
Phosphoric Monoester Hydrolases / chemistry
-
Phosphoric Monoester Hydrolases / genetics
-
RNA-Dependent RNA Polymerase / chemistry
-
RNA-Dependent RNA Polymerase / genetics
-
Sequence Homology, Nucleic Acid
-
Solubility
-
Viral Proteins / chemistry
-
Viral Proteins / genetics*
Substances
-
Viral Proteins
-
RNA-Dependent RNA Polymerase
-
Phosphoric Monoester Hydrolases
-
Chymotrypsin
-
Nucleoside-Triphosphatase