Hormonal and nutritional control of L-carnitine uptake in myoblastic C2C12 cells

Muscle Nerve. 2008 Jul;38(1):912-5. doi: 10.1002/mus.21008.

Abstract

L-Carnitine plays an important role in skeletal muscle bioenergetics, and its bioavailability and thus its import may be crucial for muscle function. We studied the effect of thyroid hormone, insulin, and iron overload, hormones and nutrients known to alter muscle metabolism, on L-carnitine import into C2C12 cells. We report here L-carnitine uptake is increased by thyroid hormones and decreased by iron. Insulin was found to be ineffective in altering the L-carnitine uptake.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Northern
  • Carnitine / metabolism*
  • Cell Line
  • Hormones / physiology*
  • Humans
  • Insulin / pharmacology
  • Iron Compounds / pharmacology
  • Iron Overload / metabolism
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / metabolism*
  • Nutritional Physiological Phenomena / physiology*
  • Organic Cation Transport Proteins / biosynthesis
  • Organic Cation Transport Proteins / genetics
  • RNA, Messenger / biosynthesis
  • Solute Carrier Family 22 Member 5
  • Triiodothyronine / pharmacology

Substances

  • Hormones
  • Insulin
  • Iron Compounds
  • Organic Cation Transport Proteins
  • RNA, Messenger
  • SLC22A5 protein, human
  • Solute Carrier Family 22 Member 5
  • Triiodothyronine
  • Carnitine