Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission

J Infect Dis. 2008 Jul 1;198(1):68-71. doi: 10.1086/588710.

Abstract

To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals in China. The carrier frequency of a DC-SIGN allele with <5 repeat units in the neck-region was 0.9% in HIV-1-positive and 3.8% in HIV-1-negative individuals (P=.007), an observation suggesting that this DC-SIGN variation plays a role in HIV-1 transmission. These naturally occurring DC-SIGN neck-region variants were significantly more frequent in the Chinese population than in the US population (P <.001) and in a worldwide population (P=.006).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Case-Control Studies
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / genetics*
  • China
  • Female
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genotype
  • HIV Infections / genetics
  • HIV Infections / transmission*
  • HIV-1*
  • Humans
  • Lectins, C-Type / chemistry
  • Lectins, C-Type / genetics*
  • Male
  • Odds Ratio
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / genetics*

Substances

  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • Lectins, C-Type
  • Receptors, Cell Surface