Abstract
The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amides / chemistry
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Amination
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Combinatorial Chemistry Techniques
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Hydrogen / chemistry*
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Molecular Structure
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Naphthyridines / chemical synthesis*
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Naphthyridines / chemistry
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Oxidation-Reduction
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Sulfonamides / chemistry
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Urea / chemistry
Substances
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Amides
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Naphthyridines
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Sulfonamides
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Hydrogen
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Urea