Abstract
Contemporary literature lacks a definition of prior antibiotic exposure which captures all patients at risk of developing piperacillin-tazobactam-resistant Pseudomonas aeruginosa (PTR-PA). The results indicated that individual antibiotics that are associated with PTR-PA differ depending on the definition of prior antibiotic exposure utilized. When the specific antibiotic used was replaced by the number of prior exposures, the number of exposures was the only variable associated with an increased risk of antibiotic resistance at each time threshold.
MeSH terms
-
Aged
-
Anti-Bacterial Agents / adverse effects
-
Anti-Bacterial Agents / pharmacology
-
Anti-Bacterial Agents / therapeutic use*
-
Drug Resistance, Multiple, Bacterial
-
Female
-
Humans
-
Male
-
Middle Aged
-
Penicillanic Acid / adverse effects
-
Penicillanic Acid / analogs & derivatives
-
Penicillanic Acid / pharmacology
-
Penicillanic Acid / therapeutic use
-
Piperacillin / adverse effects
-
Piperacillin / pharmacology
-
Piperacillin / therapeutic use
-
Piperacillin, Tazobactam Drug Combination
-
Pseudomonas Infections / drug therapy*
-
Pseudomonas Infections / microbiology
-
Pseudomonas aeruginosa / drug effects*
-
Respiratory Tract Infections / drug therapy*
-
Respiratory Tract Infections / microbiology
-
Retrospective Studies
-
Risk Factors
Substances
-
Anti-Bacterial Agents
-
Piperacillin, Tazobactam Drug Combination
-
Penicillanic Acid
-
Piperacillin