Abstract
Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both blood and mosquito stages, and against blood-stage Trypanosoma brucei brucei.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antimalarials / pharmacology*
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Cell Membrane / metabolism*
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Humans
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Molecular Sequence Data
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Parasitic Sensitivity Tests
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Peptides / chemistry
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Peptides / pharmacology*
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Peptides / therapeutic use
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / growth & development
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Trypanocidal Agents / pharmacology*
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Trypanosoma brucei brucei / drug effects*
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Trypanosoma brucei brucei / growth & development
Substances
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Antimalarials
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Peptides
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Trypanocidal Agents