Isolated ACTH deficiency with absent response to corticotrophin-releasing factor--41. Evidence for a primary pituitary defect

Acta Paediatr Scand. 1991 Feb;80(2):259-61. doi: 10.1111/j.1651-2227.1991.tb11845.x.

Abstract

An 8-year-old girl presenting in hypoglycaemic coma was shown to have isolated deficiency of adrenocorticotrophic hormone (ACTH) secretion. Failure to secrete ACTH in response to intravenous administration of synthetic ovine corticotrophin-releasing factor (CRF-41) suggests that this disorder was due to a primary pituitary defect, rather than of hypothalamic origin.

Publication types

  • Case Reports

MeSH terms

  • Adrenocorticotropic Hormone / deficiency*
  • Child
  • Corticotropin-Releasing Hormone
  • Female
  • Humans
  • Hypoglycemia / diagnosis*
  • Hypoglycemia / etiology
  • Pituitary Diseases / complications
  • Pituitary Diseases / diagnosis*
  • Pituitary Function Tests

Substances

  • Adrenocorticotropic Hormone
  • Corticotropin-Releasing Hormone