Abstract
In this issue of Cell Stem Cell, Belema-Bedada et al. (2008) describe a novel mechanism by which bone marrow-derived adult mesenchymal stem cells migrate to sites of damaged heart tissue. This process is dependent on the intracellular adaptor molecule FROUNT, which interacts with the chemokine receptor CCR2.
Publication types
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Introductory Journal Article
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Comment
MeSH terms
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Adult Stem Cells / cytology*
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Adult Stem Cells / metabolism*
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Animals
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Bone Marrow Cells / cytology
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Bone Marrow Cells / metabolism
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Cell Migration Assays
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Cell Movement*
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Clathrin Heavy Chains / genetics*
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Clathrin Heavy Chains / metabolism*
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Mesenchymal Stem Cells / cytology*
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Mesenchymal Stem Cells / metabolism*
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Mice
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Myocardium / pathology
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Oligonucleotide Array Sequence Analysis
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Organ Specificity
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Receptors, CCR2 / genetics
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Receptors, CCR2 / metabolism*
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Reperfusion Injury / blood
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Reperfusion Injury / pathology
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Transgenes / genetics
Substances
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Ccr2 protein, mouse
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FROUNT protein, mouse
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Receptors, CCR2
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Clathrin Heavy Chains