Complete and unambiguous assignments of 1H and 13C chemical shifts of new arylamino derivatives of ortho-naphthofuranquinones

Eufrânio N da Silva Júnior; Maria Cecília B V de Souza; Antônio V Pinto; Maria do Carmo F R Pinto; Christiane M Nogueira; Vitor F Ferreira; Rodrigo B V Azeredo

doi:10.1002/mrc.2250

Complete and unambiguous assignments of 1H and 13C chemical shifts of new arylamino derivatives of ortho-naphthofuranquinones

Magn Reson Chem. 2008 Dec;46(12):1158-62. doi: 10.1002/mrc.2250.

Authors

Eufrânio N da Silva Júnior¹, Maria Cecília B V de Souza, Antônio V Pinto, Maria do Carmo F R Pinto, Christiane M Nogueira, Vitor F Ferreira, Rodrigo B V Azeredo

Affiliation

¹ Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Campus do Valonguinho, 24020-141, Niterói, RJ, Brazil.

PMID: 18524015
DOI: 10.1002/mrc.2250

Abstract

Six new nor-beta-lapachones have been synthesized from reaction of 3-bromo-nor-beta-lapachone with arylamines. These derivatives have potent anticancer properties against several cell lines. Here, we report complete unambiguous assignments of (1)H and (13)C chemical shifts of the new compounds. The assignments were made using a combination of one- and two-dimensional NMR techniques ((1)H, (13)C, (1)H-(1)H COSY, (1)H-(13)C HSQC, and (1)H-(13)C HMBC).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry
Antineoplastic Agents / chemistry
Carbon Isotopes
Furans / chemistry
Magnetic Resonance Spectroscopy / methods*
Naphthalenes / chemistry
Quinones / chemistry*

Substances

Amines
Antineoplastic Agents
Carbon Isotopes
Furans
Naphthalenes
Quinones