Abstract
The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.
MeSH terms
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Animals
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Candida albicans / metabolism
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Candida glabrata / metabolism
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Carbon / chemistry
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Chemistry, Pharmaceutical / methods
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Drug Design
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Humans
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Models, Chemical
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Molecular Conformation
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Oxygen / chemistry
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Reactive Oxygen Species
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Sphingosine / analogs & derivatives*
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Sphingosine / chemical synthesis
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Sphingosine / chemistry
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Technology, Pharmaceutical / methods
Substances
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Antifungal Agents
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Reactive Oxygen Species
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Carbon
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phytosphingosine
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Sphingosine
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safingol
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Oxygen