A synthesis of N-bridged 5,6-bicylic pyridines via a mild cyclodehydration using the burgess reagent and discovery of a novel carbamylsulfonylation reaction

Org Lett. 2008 Jul 3;10(13):2897-900. doi: 10.1021/ol8011748. Epub 2008 Jun 6.

Abstract

Cyclodehydration using the Burgess reagent provided a novel approach toward the synthesis of N-bridged 5,6-bicylic pyridines including pyrolo-, imidazo-, and triazolopyridines under mild and neutral conditions. The methodology tolerates acid-sensitive functional groups. A novel addition product was observed between the resulting pyrrolo- or imidazopyridine and an additional equivalent of the Burgess reagent, producing the corresponding sulfonylcarbamate adduct.

MeSH terms

  • Carbamates / chemistry*
  • Crystallography, X-Ray
  • Cyclization
  • Heterocyclic Compounds, 2-Ring / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Sulfur Compounds / chemistry*
  • Water / chemistry*

Substances

  • Carbamates
  • Heterocyclic Compounds, 2-Ring
  • Pyridines
  • Sulfur Compounds
  • Water