Abstract
Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Motifs*
-
Animals
-
Caenorhabditis elegans Proteins / chemistry
-
Caenorhabditis elegans Proteins / classification
-
Computational Biology / methods*
-
DNA-Binding Proteins / chemistry
-
DNA-Binding Proteins / classification
-
Drosophila Proteins / chemistry
-
Drosophila Proteins / classification
-
Evolution, Molecular
-
GTPase-Activating Proteins / chemistry*
-
GTPase-Activating Proteins / classification*
-
Humans
-
Phylogeny
-
Protein Structure, Tertiary
-
Saccharomyces cerevisiae / chemistry
-
Saccharomyces cerevisiae Proteins / chemistry
-
Saccharomyces cerevisiae Proteins / classification
-
Sequence Alignment
Substances
-
Caenorhabditis elegans Proteins
-
DNA-Binding Proteins
-
Drosophila Proteins
-
GTPase-Activating Proteins
-
Saccharomyces cerevisiae Proteins