The relationship between angiotensin-converting enzyme insertion/deletion polymorphism and proliferative retinopathy in type 2 diabetes

Mostafa Feghhi; Abdolrahim Nikzamir; Alireza Esteghamati; Fereidoon Farahi; Manouchehr Nakhjavani; Armin Rashidi

doi:10.1016/j.diabres.2008.04.021

The relationship between angiotensin-converting enzyme insertion/deletion polymorphism and proliferative retinopathy in type 2 diabetes

Diabetes Res Clin Pract. 2008 Sep;81(3):e1-4. doi: 10.1016/j.diabres.2008.04.021. Epub 2008 Jun 9.

Authors

Mostafa Feghhi¹, Abdolrahim Nikzamir, Alireza Esteghamati, Fereidoon Farahi, Manouchehr Nakhjavani, Armin Rashidi

Affiliation

¹ Department of Ophthalmology, Faculty of Medicine, Ahwaz Jondi Shapour University of Medical Sciences, Ahwaz, Iran.

PMID: 18541327
DOI: 10.1016/j.diabres.2008.04.021

Abstract

A total of 136 type 2 diabetic patients with nonproliferative and 94 patients with proliferative diabetic retinopathy (PDR) without nephropathy were studied. The DD genotype of the angiotensin-converting enzyme polymorphism was more common in the PDR group (P<0.001). In multivariate regression, the association remained significant (OR=3.516).

MeSH terms

Aged
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / genetics*
Diabetic Angiopathies / genetics
Diabetic Retinopathy / genetics*
Diabetic Retinopathy / physiopathology
Female
Humans
Hypertension / genetics
Male
Middle Aged
Multivariate Analysis
Mutagenesis, Insertional*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Regression Analysis
Sequence Deletion*

Substances

Peptidyl-Dipeptidase A