Abstract
Beta-lactam antibiotics (BLAs) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / pharmacology
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Drug Resistance, Bacterial / genetics
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Microbial Sensitivity Tests
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Models, Genetic
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Molecular Sequence Data
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Penicillin-Binding Proteins / genetics*
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Point Mutation*
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Sequence Homology, Amino Acid
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Streptococcus agalactiae / drug effects*
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Streptococcus agalactiae / genetics
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Streptococcus agalactiae / metabolism
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beta-Lactams / pharmacology*
Substances
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Anti-Bacterial Agents
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Penicillin-Binding Proteins
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beta-Lactams
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PBP 2x protein, Streptococcus