Transformation of cutaneous gamma/delta T-cell lymphoma following 15 years of indolent behavior

J Cutan Pathol. 2008 Nov;35(11):1063-7. doi: 10.1111/j.1600-0560.2007.00931.x. Epub 2008 Jun 9.

Abstract

Subcutaneous gamma/delta (gamma/delta) T-cell lymphoma is a rare lymphoma, characterized by its unique immunophenotype and clinical course. It has been shown to behave more aggressively than its counterpart bearing the alpha/beta receptor and has recently been removed from the subcutaneous panniculitis-like T-cell lymphoma category for this very reason. We present a case of a patient with a 15-year running diagnosis of panniculitis. Following these years of indolent behavior, the disease began an aggressive clinical course and she was diagnosed with gamma/delta T-cell lymphoma. Molecular analysis identified a T-cell clone, which through retrospective analysis, was also shown to be present in the patient's original biopsy material. We present this case as a rare example of initial indolent behavior in a lymphoma typically considered very aggressive.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carboplatin / administration & dosage
  • Carboplatin / therapeutic use
  • Cell Transformation, Neoplastic / pathology*
  • Clone Cells
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / therapeutic use
  • Doxorubicin / administration & dosage
  • Doxorubicin / therapeutic use
  • Etoposide / administration & dosage
  • Etoposide / therapeutic use
  • Fatal Outcome
  • Female
  • Humans
  • Ifosfamide / administration & dosage
  • Ifosfamide / therapeutic use
  • Lymphoma, T-Cell, Cutaneous / drug therapy
  • Lymphoma, T-Cell, Cutaneous / genetics
  • Lymphoma, T-Cell, Cutaneous / metabolism
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Middle Aged
  • Panniculitis / pathology*
  • Prednisone / administration & dosage
  • Prednisone / therapeutic use
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism*
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / genetics
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*
  • T-Lymphocytes / pathology
  • Vincristine / administration & dosage
  • Vincristine / therapeutic use

Substances

  • Receptors, Antigen, T-Cell, gamma-delta
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Carboplatin
  • Ifosfamide
  • Prednisone

Supplementary concepts

  • CHOP protocol
  • ICE protocol 3