Dermatologic immune restoration syndrome: report of five cases from a tertiary care center in north India

J Cutan Med Surg. 2008 May-Jun;12(3):126-32. doi: 10.2310/7750.2008.07017.

Abstract

Background: Dermatologic conditions are often an early clue to human immunodeficiency virus (HIV) infection. As the disease progresses and the host immunity fails, patients may develop a number of skin conditions. At this point, they have a dominant T helper 2 immunologic response. After the initiation of antiretroviral therapy, the T helper 1 response is restored, and some skin problems, paradoxically, make their appearance then.

Conclusion: Herpes zoster, mucocutaneous herpes, eosinophilic folliculitis, and mycobacterial infections have been known to occur at this stage. This may be because immune restoration of a host's immunity causes recognition of silent or latent infection and results in development of the condition. We report five cases that were seen at our center during a 2-year period.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis
  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / immunology*
  • Adult
  • Animals
  • CD4 Lymphocyte Count
  • Diagnosis, Differential
  • Female
  • HIV Infections / immunology*
  • Herpes Zoster / diagnosis
  • Herpes Zoster / drug therapy
  • Herpes Zoster / immunology
  • Humans
  • India
  • Leprosy / diagnosis
  • Leprosy / drug therapy
  • Leprosy / immunology
  • Male
  • Mite Infestations / diagnosis
  • Mite Infestations / drug therapy
  • Mite Infestations / immunology
  • Prognosis
  • Skin Diseases / diagnosis
  • Skin Diseases / drug therapy
  • Skin Diseases / immunology*
  • Syndrome
  • Tuberculosis, Cutaneous / diagnosis
  • Tuberculosis, Cutaneous / drug therapy
  • Tuberculosis, Cutaneous / immunology
  • Viral Load