Unplanned surgery after drug eluting stent implantation: a strategy for safe temporary withdrawal of dual oral antiplatelet therapy

J Cardiovasc Med (Hagerstown). 2008 Jul;9(7):737-41. doi: 10.2459/JCM.0b013e3282f37e58.

Abstract

We describe four cases of patients with multiple coronary drug eluting stent implantation who underwent major surgery (cardiac and noncardiac) early after stent implantation and needed premature interruption of dual antiplatelet therapy. The transitory withdrawal of oral antiplatelet therapy was accomplished without complications with the use of an IIb/IIIa glycoprotein inhibitor (Tirofiban).

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Aged
  • Angioplasty, Balloon, Coronary
  • Aspirin*
  • Clopidogrel
  • Contraindications
  • Drug Therapy, Combination
  • Drug-Eluting Stents*
  • Fibrinolytic Agents / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors*
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors
  • Preoperative Care*
  • Surgical Procedures, Operative
  • Ticlopidine / analogs & derivatives*
  • Tirofiban
  • Tyrosine / analogs & derivatives*
  • Tyrosine / therapeutic use

Substances

  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Tyrosine
  • Clopidogrel
  • Tirofiban
  • Ticlopidine
  • Aspirin