Dictazolines A and B, bisspiroimidazolidinones from the marine sponge Smenospongia cerebriformis

J Nat Prod. 2008 Jul;71(7):1287-90. doi: 10.1021/np8001018. Epub 2008 Jun 12.

Abstract

An extensive study of the secondary metabolites produced by the marine sponge Smenospongia cerebriformis has led to the isolation of two new bisspiroimidazolidinone derivatives, dictazolines A (1) and B (2), along with the known soft coral metabolites tubastrindoles A (3) and B (4). The structures were assigned by 2D NMR spectroscopic methods.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anthozoa / chemistry
  • Imidazoles / chemistry
  • Imidazoles / isolation & purification*
  • Indoles / chemistry
  • Indoles / isolation & purification*
  • Marine Biology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Spiro Compounds / chemistry
  • Spiro Compounds / isolation & purification*

Substances

  • Imidazoles
  • Indoles
  • Spiro Compounds
  • dictazoline A
  • dictazoline B
  • tubastrindole A
  • tubastrindole B