Association between 16S-23S internal transcribed spacer sequence groups of Mycobacterium avium complex and pulmonary disease

J Clin Microbiol. 2008 Aug;46(8):2790-3. doi: 10.1128/JCM.00719-08. Epub 2008 Jun 11.

Abstract

Organisms within the Mycobacterium avium complex (MAC) may have differential virulence. We compared 33 subjects with MAC pulmonary disease to 75 subjects with a single positive culture without disease. M. avium isolates were significantly more likely to be associated with MAC pulmonary disease (odds ratio = 5.14, 95% confidence interval = 1.25 to 22.73) than M. intracellulare.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Case-Control Studies
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal Spacer / genetics*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mycobacterium avium / genetics*
  • Mycobacterium avium / pathogenicity*
  • Mycobacterium avium Complex / genetics*
  • Mycobacterium avium Complex / pathogenicity*
  • Phylogeny
  • Sequence Analysis, DNA
  • Tuberculosis, Pulmonary / microbiology*
  • Virulence

Substances

  • DNA, Bacterial
  • DNA, Ribosomal Spacer